منابع مشابه
Excitation BolsTORs Motor Neurons in ALS Mice
It is unclear why motor neurons selectively degenerate in amyotrophic lateral sclerosis (ALS). Saxena et al. (2013) demonstrate that excitation of motor neurons can prevent their demise in a mouse model of inherited ALS by a mechanism involving the mTOR pathway.
متن کاملThings we observed when watching people walk: Classification of gait patterns with self-organizing maps
Clinical observation and the evaluation of the various locomotive patterns in human walk is the subject of gait analysis. We suggest a novel approach to gait pattern classification as a tool for subsequent medical diagnosis and therapy considerations. Based on data collected from patients at an rehabilitation centre we achieve a clustering according to various gait malfunctions by using self-or...
متن کاملMembrane Watching
Several things, that were not all of my own choosing, have conspired to keep me out of active participation in membrane events for a while. But the spectator sport that I call "membrane watching" is far from dull. It may be as rewarding as such things as birds, Congress, girls, bali games, or the Berkeley campus-particularly when you feel yourself somewhat qualified. Of course you lose the trem...
متن کاملC9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC
For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.
متن کاملHyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice.
ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative disease characterized by a progressive and selective loss of motoneurons. Transgenic mice overexpressing a mutated human gene (G93A) coding for the enzyme SOD1 (Cu/Zn superoxide dismutase) develop a motoneuron disease resembling ALS in humans. In this generally accepted ALS model, we tested the electrophysiologic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lab Animal
سال: 2017
ISSN: 0093-7355,1548-4475
DOI: 10.1038/laban.1191